Agent Name

Diisooctyl phthalate

CAS Number

27554-26-3

Formula

C24-H38-O4

Major Category

Plastics & Rubber

Synonyms

1,2-Benzenedicarboxylic acid, diisooctyl ester; Corflex 880; Di-iso-octyl phthalate; Diisooctyl 1,2-benzenedicarboxylate; DIOP; Flexol Plasticizer DIOP; Genomoll 100; Hexaplas M/O; Isooctyl phthalate; Phthalic acid, bis(6-methylheptyl)ester; Phthalic acid, diisooctyl ester; [ChemIDplus]

Category

Phthalate Esters

Description

Nearly colorless viscous liquid; [Hawley] Clear colorless viscous liquid; [MSDSonline]

Sources/Uses

Used as plasticizer for polyvinyl chloride jackets for building wire, cellulosic and acrylate resins, and synthetic rubber; Also used as a penetration agent for fungicides; Permitted for use as an additive in plastics in contact with food in Italy and the US; [HSDB]

Comments

There is confusion in the naming of the dioctyl phthalate esters: Di-n-octyl phthalate, Di-sec-octyl phthalate, and Diisooctyl phthalate. [CHEMINFO] Female mice fed >190 mg/kg/bw have weight loss and show increased resorptions, fetal malformations, and late fetal deaths; Mice fed 426 mg/kg/day show increased liver weight as well as reproductive effects; Oral LD50 (mouse) >26,000 mg/kg; Dioctyl phthalate may cause CNS depression and mild liver toxicity after ingestion of large amounts; [HSDB] No listed effects of short-term or long-term exposure; [ICSC] May cause irritation and liver damage; [MSDSonline] See "PHTHALATE ESTERS."

Exposure Assessment
Vapor Pressure

5.5E-6 mm Hg

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Processes

Industrial Processes with risk of exposure: