Agent Name

Diisopropyl fluorophosphate

Alternative Name

Isoflurophate

CAS Number

55-91-4

Formula

C6-H14-F-O3-P

Major Category

Pesticides

Synonyms

Isoflurophate; DFP; Diflupyl; Diflurophate; Diisopropoxyphosphoryl fluoride; Diisopropyl fluorophosphonate; Diisopropyl phosphofluoridate; Diisopropyl phosphorofluoridate; Diisopropylfluorfosfat [Czech]; Diisopropylfluorophosphate; Diisopropylfluorophosphoric acid ester; Diisopropylfluorphosphorsaeureester [German]; Diisopropylphosphorofluoridate; Dyflos; EA 1152; Floropryl; Fluophosphoric acid, diisopropyl ester; Fluorodiisopropyl phosphate; Fluorophosphoric acid, diisopropyl ester; Fluostigmine; Isofluorophate; Isoflurophosphate; Isopropyl fluophosphate; Isopropyl phosphorofluoridate; Neoglaucit; O,O'-Diisopropyl phosphoryl fluoride; O,O-Diisopropyl fluorophosphate; PF-3; Phosphorofluoridic acid, bis(1-methylethyl) ester; Phosphorofluoridic acid, diisopropyl ester; T-1703; TL 466; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Clear colorless or slightly yellow liquid; [HSDB] Clear colorless liquid; [MSDSonline]

Sources/Uses

Used as insecticide, cholinergic for glaucoma treatment, and veterinary miotic; [HSDB]

Comments

Produces hydrogen fluoride on exposure to moisture; Extremely toxic cholinesterase inactivator; [Merck Index] Causes irritation and injury to skin and eyes; Vapor highly irritating to eyes and mucous membranes and causes miosis in trace amounts; Cholinesterase inhibitor that is highly toxic by skin absorption and inhalation; Symptoms of heavy exposure could include convulsions, cyanosis, pulmonary edema, and coma; [EPA OHM/TADS] Effects in high-dose animal studies include miosis, true cholinesterase inhibition, fasciculations, convulsions, and coma; [RTECS] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

No longer registered as a pesticide for use in the US; [HSDB]

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

0.57 mm Hg

Lethal Concentration

LC50 (rat) = 360 mg/m3/10min

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: