Agent Name

Fluorine

CAS Number

7782-41-4

Formula

F2

Major Category

Toxic Gases & Vapors

Synonyms

Bifluoriden [Dutch]; Fluor; Fluor [Dutch, French, German, Polish]; Fluorine; Fluorine-19; Fluoro [Italian]; Fluorures acide [French]; Fluoruri acidi [Italian]; Saeure fluoride [German]; [ChemIDplus] UN1045

Category

Oxidizers

Description

Pale-yellow to greenish gas with a pungent, irritating odor; [NIOSH] Vapor density = 1.31 (heavier than air); [Burke, p. 100]

Sources/Uses

Used in the production of rocket fuel and in the synthesis of organic compounds; [ACGIH]

Comments

Fluorine gas is a severe irritant to the eyes, skin, and respiratory tract. Liver injury has been reported in experimental animals exposed to high concentrations. [ACGIH] Liquid causes second and third degree burns after short skin exposure; [CHRIS] Highly corrosive to skin; [Quick CPC] A lachrymator; [CHEMINFO] May cause respiratory tract irritation and pulmonary edema; Evaporating liquid can cause frostbite; [ICSC]

Reference Link

ATSDR ToxFAQs - Fluorine, Hydrogen Fluoride, and Fluorides

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TIH

Yes

TLV (ACGIH)

1 ppm

STEL (ACGIH)

2 ppm

PEL (OSHA)

0.1 ppm

IDLH (NIOSH)

25 ppm

Excerpts from Documentation for IDLHs

Human data: It has been reported that 2 men were able to tolerate 25 ppm very briefly but both developed sore throats and chest pains that lasted 6 hours; 50 ppm could not be tolerated [Rickey 1959]. Volunteers tolerated 10 ppm for 15 minutes with a minimum of irritation [Ricca 1970]. Intermittent exposures to 10 ppm were repeated every 3 to 5 minutes for 15 minutes over 2 to 3 hours with only slight irritation of the eyes and skin noted [Ricca 1970]. Much irritation of the eyes have been noted at 100 ppm, but with no aftereffects after only 30 seconds [Grant 1974]. It has been observed that exposures up to 30 ppm for 5 to 30 minutes had no ill effects [Lyon 1962].

Odor Threshold Low

0.09 ppm

Odor Threshold High

0.19 ppm

Lethal Concentration

LC50 (rat) = 185 ppm/1H

Explanatory Notes

Odor threshold from AIHA; See "2018 Notice of Intended Changes." [TLVs and BEIs]

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: