Agent Name

Formamide

CAS Number

75-12-7

Formula

C-H3-N-O

Major Category

Solvents

Synonyms

Amid kyseliny mravenci [Czech]; Carbamaldehyde; Formamide; Formic acid, amide; Formimidic acid; Methanamide; Methanoic acid, amide; [ChemIDplus] UN8027

Category

Amides (<C10)

Description

Colorless, oily liquid. [Note: A solid below 37 degrees F.]; [NIOSH]

Sources/Uses

Used as a chemical intermediate and ionizing solvent; also used as a softener for glues, gums, and paper; [ACGIH]

Comments

Subchronic studies of rats exposed at 1500 ppm show decreased weight gain, kidney injury, and suppression of platelets and lymphocytes. By analogy with dimethylformamide, formamide is a suspected liver toxin. [ACGIH] A skin and eye irritant; Inhalation of high concentrations may cause CNS effects; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

10 ppm

Vapor Pressure

0.06 mm Hg

Explanatory Notes

Flash point = 310 deg F;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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