Agent Name

Dioscorine

CAS Number

3329-91-7

Formula

C13-H19-N-O2

Major Category

Biological Agents

Synonyms

Spiro(2-azabicyclo(2.2.2)octane-5,2'-(2H)pyran)-6'(3'H)- one, 2,4'-dimethyl-, (1R-(1alpha,4alpha,5alpha))-; [ChemIDplus]

Category

Plant Toxins

Description

Greenish-yellow solid; [MSDSonline]

Sources/Uses

Naturally occurring alkaloid in toxic yams of the genus dioscorea; [HSDB]

Comments

Has a picrotoxin-like action; Emergency treatment: Symptomatic plant ingestion; [HSDB] Picrotoxin is a GABA antagonist that causes seizures. [Ford, p. 156] Intraperitoneal LD50 (mouse) = 60 mg/kg; Causes seizures at lethal doses; [RTECS]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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