Agent Name

Furfuryl alcohol

CAS Number

98-00-0

Formula

C5-H6-O2

Major Category

Other Classes

Synonyms

2-Furancarbinol; 2-Furanmethanol; 2-Furanylmethanol; 2-Furfuryl alcohol; 2-Furfurylalkohol [Czech]; 2-Furylcarbinol; 2-Furylmethanol; 2-Hydroxymethylfuran; 5-Hydroxymethylfuran; Furfural alcohol; Furfuralcohol; Furfuranol; Furfuryl alcohol; Furfurylcarb; Furyl alcohol; Furylcarbinol (VAN); Methanol, (2-furyl)-; alpha-Furylcarbinol; [ChemIDplus] UN2874

Category

Alcohols and Polyols, Other

Description

Colorless to amber liquid with a faint, burning odor. [Note: Darkens on exposure to light.]; [NIOSH]

Sources/Uses

Used as a solvent and as an intermediate in the manufacturing of resins and wetting agents; [Merck Index # 4305] Used as a solvent for tanning agents, dyes, and resins; also used in sealants, cements, and furan and urea-formaldehyde polymers; [HSDB] The most important use is in making poly(furfuryl alcohol) resins to bind sand-based cores and molds in foundries and to produce plastics, cements, mortars, binders, and adhesives. Resins made from furfuryl alcohol are chemical-resistant and nonburning. [ACGIH]

Comments

Asthma reported in a foundry mold making worker; [Malo] Furfuryl alcohol causes hypoactivity and respiratory tract lesions in high-dose inhalation studies of rats and mice. It causes liver damage in animals fed 1 mg/day for 60 days. Potential for sensitization, but insufficient data for DSEN or RSEN notations; [ACGIH] A skin, eye, and respiratory tract irritant; [ICSC] Causes lacrimation and defatting of skin; [ICSC]

Reference Link

Asthma caused by occupational exposure to a furan-based binder system

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.2 ppm

PEL (OSHA)

50 ppm

IDLH (NIOSH)

75 ppm

Excerpts from Documentation for IDLHs

Other animal data: Exposure of rats to 100 ppm for 6 hours per day, 5 days per week for 16 weeks resulted in decreased weight gain and biochemical changes in the brain (i.e., increased cerebral glial acidproteinase and phosphohydrase activity) [Savolainen and Pfaffli 1983]. Human data: No discomfort was reported from concentrations up to 10.8 ppm for 15 minutes, but severe lacrimation occurred at 15.8 ppm [Apol 1973]. It has also been reported that there is no hazard from exposures up to 16 ppm [Burton and Rivera 1972].

Vapor Pressure

0.61 mm Hg

Odor Threshold Low

8 ppm

Lethal Concentration

LC50 (rat) = 233 ppm/4 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 8.0 ppm); Flash point = 75 deg C;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Lacrimator

Yes

Asthma

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: