Agent Name

Dipropylene glycol

Alternative Name

DPG

CAS Number

25265-71-8

Formula

C6-H14-O3

Major Category

Other Classes

Synonyms

Dipropylene glycol (6CI); Dipropylenglykol; Oxybispropanol; Propanol, oxybis-; DPG; [ChemIDplus]

Category

Propylene Glycols

Description

Colorless, odorless liquid; [HSDB] Hygroscopic; [CHEMINFO]

Sources/Uses

Used in antifreeze, air sanitizers, cosmetic stabilizers, polyester and alkyd resins, reinforced plastics, plasticizers, solvents, and steam set printing inks; [HSDB] Used in hydraulic break fluids, cutting oils, textile lubricants, industrial soaps, pesticide solvents, fragrances, skin care products, deodorants, hair care products, shaving products, facial makeup, and bath and shower products; [CHEMINFO]

Comments

Readily absorbed by GI tract and metabolically converted into propylene glycol; No deaths in animals inhaling 6-8 g/m3; 30% of rats exposed to 10% DPG in drinking water have kidney lesions; No fetal toxicity or teratogenicity in rats; [Reference #1] May cause minor eye irritation; [CAMEO] Commercial dipropylene glycol (CAS # 25265-71-8) is composed of 3 isomers: (2,2' -dihydroxydiisopropropylether (CAS # 108-61-2); 2,2' -dihydroxydipropylether (CAS # 110-98-5); 2-hydroxypropyl-2'-hydroxyisopropylether (CAS # 106-62-7); [eChemPortal: SIDSUNEP] Causes mainly kidney and also liver and testicular injury in high-dose feeding studies of experimental animals; Oral LD50 (rat) = 14.8 ml/kg; [HSDB] May cause irritation; [MSDSonline] See "Propylene glycol."

Reference Link

OECD SIDS: Dipropylene glycol (mixed isomers and dominant isomer) - 2001

Exposure Assessment
MAK

100 mg/m3, inhalable fraction

Vapor Pressure

0.03 mm Hg

Explanatory Notes

Flash point = 120 deg C; [HSDB]

Reference Link

EPA REDs: Propylene glycol and Dipropylene glycol - 2006

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: