Agent Name

Glycidol

Alternative Name

2,3-Epoxy-1-propanol

CAS Number

556-52-5

Formula

C3-H6-O2

Major Category

Plastics & Rubber

Synonyms

1,2-Epoxy-3-hydroxypropane; 1-Hydroxy-2,3-epoxypropane; 1-Propanol, 2,3-epoxy-; 2,3-Epoxy-1-propanol; 2,3-Epoxypropanol; 2-(Hydroxymethyl)oxirane; 2-Hydroxymethyloxiran; 3-Hydroxy-1,2-epoxypropane; 3-Hydroxypropylene oxide; Allyl alcohol oxide; Epihydrin alcohol; Epoxypropyl alcohol; Glycide; Glycidol; Glycidyl alcohol; Hydroxymethyl ethylene oxide; Methanol, oxiranyl-; Monoepoxide glycidol; Oxiranemethanol; Oxiranylmethanol; [ChemIDplus] UN2810

Category

Epoxides

Description

Colorless, slightly viscous liquid; [HSDB]

Sources/Uses

Used primarily as a stabilizer of vinyl polymers; [ACGIH]

Comments

Mice and rats exposed to high concentrations develop pneumonitis and emphysema; Rabbits show skin irritation and reversible corneal burns after skin and eye exposure; [ACGIH] In lethal inhalation studies of rodents, pulmonary edema was usually the cause of death; There is no experimental data, but glycidol, an epoxide, should be considered a potential skin and respiratory sensitizer; [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

2 ppm

PEL (OSHA)

50 ppm

IDLH (NIOSH)

150 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956]. Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

5.59 mm Hg

Lethal Concentration

LC50 (rat) = 580 ppm/8H

Explanatory Notes

Flash point = 162 deg F; VP =0.9 mm Hg @ 25 deg C; [HSDB]

Reference Link

ICSC: Glycidol

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: