Agent Name

Domoic acid

CAS Number

14277-97-5

Formula

C15-H21-N-O6

Major Category

Biological Agents

Synonyms

L-Domoic acid; 3-Pyrrolidineacetic acid, 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-, (2S-(2-alpha,3-beta,4-beta(1Z,3E,5S*)))-; [ChemIDplus]

Category

Seafood Toxins

Description

Colorless solid; [HSDB] White powder; [MSDSonline]

Sources/Uses

Toxic amino acid isolated from a specific red alga (Chondria armata, Okamura, Rhodomelaceae); Causes amnesic shellfish poisoning; [Merck Index] Domoic acid and brevitoxin are toxins found in shellfish (mussels, oysters, and scallops) from the Florida coast and Gulf of Mexico. [MMWR. Vol. 53/RR]

Comments

Onset of action after ingestion is from minutes to hours; [Olson, p. 220] Domoic acid was found in Atlantic shellfish in 1987. It was found in crabs and clams in the states of Oregon and Washington, and in seafood from the Gulf of Mexico in Texas. Domoic acid causes gastroenteritis plus headache and loss of short term memory. [CCDM, p. 248-9] Domoic acid is water-soluble toxin that could be used as a biological weapon. After a heavy exposure, patients have gastroenteritis followed by neurological symptoms including confusion, hyporeflexia, memory loss, weakness, seizures, stupor, and coma. Patients may also have arrhythmias. [Weinstein, p. 58-9] Causes seizures at lethal doses; Intraperitoneal LD50 (mouse) = 5 mg/kg; [RTECS] May cause irritation and CNS disturbances; [MSDSonline]

Reference Link

INCHEM: Domoic acid (PIM 670)

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.