Agent Name

Cadusafos

CAS Number

95465-99-9

Formula

C10-H23-O2-P-S2

Major Category

Pesticides

Synonyms

Ebufos; FMC 67825; O-Ethyl S,S-bis(1-methylpropyl) phosphorodithioate (9CI); O-Ethyl-S,S-bis(1-methylpropyl)phosphorodithioate; O-Ethyl-S,S-di-sec-butylphosphorodithioate; Rugby; S,S-Di-sec-butyl O-ethyl phosphorodithioate; Sebufos; Sebuphos; Taredan; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Colorless to yellow liquid; [Merck Index] Pale yellow liquid; [MSDSonline]

Sources/Uses

Used for broad control of parasitic plant nematodes and soil insects in fruits, vegetables, and other crops; [HSDB] Used as nematicide and soil insecticide on bananas in Central and South America; [Reference #1]

Comments

No significant adverse effects were observed besides inhibition of cholinesterase activity in high-dose animal studies; In a two generation feeding study with rats the LOEL for reproductive toxicity was 0.5 ppm (0.025 mg/kg/day) based on marked decrease in live birth index; No evidence of teratogenicity based on studies with rabbits and rats; [HSDB] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

Not currently registered as a pesticide for use in the US; [HSDB] No US registrations; [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.001 mg/m3, inhalable fraction and vapor

Vapor Pressure

0.0009 mm Hg

Lethal Concentration

LC50 (rat) = 32 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Reference Link

INCHEM JMPR: Cadusafos - 1991

Adverse Effects
Other Poison

Organophosphate

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: