Agent Name

Hexafluoroacetone

CAS Number

684-16-2

Formula

C3-F6-O

Major Category

Toxic Gases & Vapors

Synonyms

1,1,1,3,3,3-Hexafluoro-2-propanone; 2-Propanone, 1,1,1,3,3,3-hexafluoro-; 6FK; Acetone, hexafluoro-; GC 7887; Hexafluoroacetone; Perfluoro-2-propanone; Perfluoroacetone; [ChemIDplus] UN2420

Category

Corrosive Gases

Description

Colorless gas with a musty odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]

Sources/Uses

Used in the synthesis of organic chemicals and polymers; [ACGIH]

Comments

In 4-hour inhalation studies of rats, 300 ppm is lethal, 200 ppm causes liver and kidney injury, and 100 ppm causes testicular damage; evidence of bone marrow injury is also seen; [ACGIH] Possible frostbite from contact with liquid; [NIOSH] Inhalation of vapor can cause pulmonary edema; A skin, eye, and respiratory tract irritant; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

TLV (ACGIH)

0.1 ppm

Lethal Concentration

LC50 (rat) = 275 ppm/3h

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: