Agent Name

Hexylene glycol

CAS Number

107-41-5

Formula

C6-H14-O2

Major Category

Other Classes

Synonyms

(+-)-2-Methyl-2,4-pentanediol; 1,1,3-Trimethyltrimethylenediol; 2,4-Dihydroxy-2-methylpentane; 2,4-Pentanediol, 2-methyl-; 2-Methyl pentane-2,4-diol; 2-Methyl-2,4-pentanediol; 4-Methyl-2,4-pentanediol; Diolane; Hexylene glycol; Isol; Pinakon; alpha,alpha,alpha'-Trimethyltrimethylene glycol; [ChemIDplus]

Category

Alcohols and Polyols, Other

Description

Colorless liquid with a mild, sweetish odor; [NIOSH]

Sources/Uses

Used as a solvent plasticizer in paints and lacquers; Also used in the chemical, petroleum refining, and cosmetic industries and as an additive to hydraulic fluids, inks, cement, leather, paper, and textiles; [ACGIH]

Comments

At 1000 ppm for 5 minutes, human subjects complain of eye, throat, and respiratory irritation. Oral dosing causes central nervous system depression in experimental animals. "Limited animal and human data suggesting a potential for skin sensitization were insufficient to support a DSEN notation." [ACGIH] Allergic contact dermatitis may occur; [Reference #1] A skin, eye, and respiratory tract irritant; [ICSC]

Reference Link

Skin reactions to hexylene glycol

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

25 ppm, vapor fraction

STEL (ACGIH)

50 ppm, vapor fraction (10 mg/m3, inhalable particulate matter, aerosol only)

MAK

10 ppm

Vapor Pressure

0.05 mm Hg

Odor Threshold Low

3.93 ppm

Lethal Concentration

LC50 (rat) > 310 mg/m3/1h

Explanatory Notes

Flash point = 93 deg C, closed cup; Odor threshold of 3.93 reported; [ACGIH]

Reference Link

ICSC: Hexylene glycol

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: