Agent Name

2-(2,4-Diaminophenoxy)ethanol dihydrochloride

CAS Number

66422-95-5

Formula

C8-H12-N2-O2.2Cl-H

Major Category

Nitrogen Compounds

Synonyms

2,4-Diaminophenoxyethanol 2HCl; 2,4-Diaminophenoxyethanol dihydrochloride; 2-(2,4-Diaminophenoxy)ethanol dihydrochloride; Ethanol, 2-(2,4-diaminophenoxy)-, dihydrochloride; [ChemIDplus] 4-(2-Hydroxyethoxy)-1,3-phenylenediamine dihydrochloride; [MSDSonline]

Category

Other Aromatics (Nitrogen)

Description

Solid; [MSDSonline] Light grey to light pink solid; [ToxPlanet: EC]

Sources/Uses

Used in hair dyes; [HSDB]

Comments

No evidence of mutagenicity; [HSDB] LD50 (gavage) in rats is approximately 1000 mg/kg; Irritating to eyes but not skin in rabbits; Not sensitizing to guinea pig skin; A moderate skin sensitizer based on local lymph node assay; Brown discoloration of the thyroid and spleen hemosiderosis observed in 13-week gavage study with rats at highest tested dose (100 mg/kg); Some evidence of mutagenicity; Teratogenic effects observed in rats (NOAEL for both maternal and embryo-fetal toxicity is 20 mg/kg/day); [ToxPlanet: EC] Harmful if swallowed; May cause skin sensitization; [Aldrich MSDS]

Adverse Effects
Skin Sensitizer

Yes

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