Agent Name

Ethyl methylphenylglycidate

CAS Number

77-83-8

Formula

C12-H14-O3

Major Category

Other Classes

Synonyms

3-Methyl-3-phenyloxiranecarboxylic acid, ethyl ester; 2,3-Epoxy-3-phenylbutyric acid, ethyl ester; 3-Methyl-3-phenylglycidic acid ethyl ester; Aldehyde C-16; Butanoic acid, 2,3-epoxy-3-phenyl-, ethyl ester; C-16 aldehyde; EMPG; Ethyl 2,3-epoxy-3-methyl-3-phenylpropionate; Ethyl 3-methyl-3-phenylglycidate; Ethyl 3-methyl-3-phenyloxiranecarboxylate; Ethyl alpha,beta-epoxy-beta-methylhydrocinnamate; Ethyl alpha,beta-epoxy-beta-methylphenylpropionate; Ethyl ester of 2,3-epoxy-3-phenylbutanoic acid; Ethyl(methylphenyl)glycidate; Fraeseol; Hydrocinnamic acid, alpha,beta-epoxy-beta-methyl-, ethyl ester; Oxiranecarboxylic acid, 3-methyl-3-phenyl-, ethyl ester; Strawberry aldehyde; alpha,beta-Epoxy-beta-methylhydrocinnamic acid, ethyl ester; [ChemIDplus]

Category

Esters, Other

Description

Colorless to light-yellow liquid with a strong odor like fruit or berries; [HSDB] Colorless liquid; [MSDSonline]

Sources/Uses

Used in perfumes and flavors; [Hawley]

Comments

A mutagen; Causes somnolence and change in liver enzymes in high-dose rat feeding studies; [RTECS] Acceptable daily intake = 0-0.5 mg/kg bw; [JECFA] Caused no skin irritation or sensitization in 25 human volunteers (1% in petrolatum); Effects in 16 week feeding study with rats at 10000 ppm include testicular atrophy; Observations in two year feeding study with rats include hindquarter paralysis and histopathological changes to sciatic nerve; No histopathological organ changes or evidence of carcinogenicity in long term feeding studies; [HSDB]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

No other related information on this agent was found.