Agent Name

Isoamyl acetate

Alternative Name

Isopentyl acetate

CAS Number

123-92-2

Formula

C7-H14-O2

Major Category

Solvents

Synonyms

Isopentyl acetate; 1-Butanol, 3-methyl-, acetate; 2-Methylbutyl ethanoate; 3-Methyl-1-butanol acetate; 3-Methyl-1-butyl acetate; 3-Methylbutyl acetate; 3-Methylbutyl ethanoate; Acetic acid, 3-methylbutyl ester; Acetic acid, isopentyl ester; Amyl acetate, common; Amylacetic ester; Banana oil; I-Amyl acetate; Isoamyl acetate; Isoamyl acetate (natural); Isoamyl ethanoate; Isoamylester kyseliny octove [Czech]; Isopentyl acetate; Isopentyl alcohol, acetate; Isopentyl ethanoate; Pear oil; beta-Methylbutyl acetate; [ChemIDplus] UN1993

Category

Esters (<C12)

Description

Colorless liquid with a banana-like odor; [NIOSH]

Sources/Uses

Used as an additive to aerosols and cosmetics and to fit-test respirators; [ACGIH]

Comments

Esters may induce narcosis in animal experiments, but workers' exposures are limited by irritating effects. See appendix in: [Dick RB, et al. Chemicals in the workplace: incorporating human neurobehavioral testing into the regulatory process. Am J Ind Med. 1998 May;33(5):439-53.] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] The pentyl acetates are sensory irritants in the work environment. At higher levels in animal experiments, they cause narcosis, hepatotoxicity, and developmental toxicity. [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

STEL (ACGIH)

100 ppm

PEL (OSHA)

100 ppm

MAK

50 ppm

IDLH (NIOSH)

1000 ppm

Excerpts from Documentation for IDLHs

"Isoamyl acetate is considered more irritating than butyl acetate. Exposure to 1,000 ppm for 30 minutes resulted in irritation, dyspnea, fatigue, and increased pulse [Amor 1950]. It is considered dangerous to life after 5 hours of exposure to 10,000 ppm [Browning 1965]." [NIOSH]

Vapor Pressure

5.6 mm Hg

Odor Threshold Low

0.0034 ppm

Odor Threshold High

209 ppm

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.22 ppm); Flash point = 77 deg F;

Half Life

No reports found; [TDR, p. 95]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: