Agent Name

Fenitrothion

CAS Number

122-14-5

Formula

C9-H12-N-O5-P-S

Major Category

Pesticides

Synonyms

3-Methyl-4-nitrophenyl dimethyl phosphorothioate; 8057HC; AC-47300; Accothion; Agria 1050; Agriya 1050; Agrothion; Akotion; American Cyanamid CL-47,300; Arbogal; BAY 41831; Bayer 41831; Bayer S 5660; C-9146; CL 47300; CP 47114; Cekutrothion; Cyfen; Cytel; Dimethyl (3-methyl-4-nitrophenyl) thiophosphate; Dimethyl 3-methyl-4-nitrophenyl phosphorothionate; Dimethyl 4-nitro-m-tolyl phosphorothionate; Dimethyl-(3-methyl-4-nitrophenyl)thiophosphate; EI 47300; ENT 25,715; Falithion; Fenition; Fenitox; Fenitrotion (Hungarian); Fentrothione; Folithion; Folithion EC 50; Insectigas F; Kotion; MEP (pesticide); Macbar; Metathion; Metathion E 50; Metathione; Metathionine; Metathionine E50; Metation; Metation E50; Methylnitrophos; Mglawik F; Monsanto CP 47114; Nitrophos; Novathion; Nuvanol; O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate; O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate; O,O-Dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate; O,O-Dimethyl O-(4-nitro-3-methylphenyl) thiophosphate; O,O-Dimethyl O-(4-nitro-3-methylphenyl)thiophosphate; O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate; O,O-Dimethyl-O-(3-methyl-4-nitro-phenyl)-monothiophosphat [German]; O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat [Dutch]; O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat [German]; O,O-Dimetil-O-(3-metil-4-nitro-fenil)-monotiofosfato [Italian]; O,O-Dimetil-O-(3-metil-4-nitrofenil) fosforotioato (Portugese); OMS 43; Oleosumifene; Ovadofos; Owadofos; Owadophos; Pennwalt C-4852; Phenitrothion; Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester; Phosphorothioic acid, O,O-dimethyl O-(4-nitro-m-tolyl) ester; S 112A; S-1102A; Sumifene; Sumithion; Sumitomo S-1102A; Super Sumithion; Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-nitrophenyle) [French]; Tionofosforan O,O-dwumetylo-O-(3-metylo)-4-nitrofenylowy [Polish]; Verthion; m-Cresol, 4-nitro-, O-ester with O,O-dimethyl phosphorothioate; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellow liquid; [Merck Index] Brown to yellow liquid; mp = 0.3 deg C; [ICSC] Yellow or yellowish-brown liquid; mp = 3.4 deg C; [HSDB] Brown-yellow liquid; mp = 3.4 deg C; [MSDSonline]

Sources/Uses

Used as insecticide and acaricide for cereals, cotton, orchard fruits, rice, vegetables, forestry, turf, greenhouses, animal houses, public health, and stored products; [HSDB] Used in Australia on stored wheat; Only registered in the US for use in ant and roach bait containers; [Reference #1]

Comments

A skin and eye irritant; Can be absorbed through skin; A cholinesterase inhibitor that may affect the nervous system causing convulsions, respiratory failure, and death; [ICSC] Some evidence of contact dermatitis following exposure; No evidence of delayed neurotoxicity; [HSDB] A very toxic cholinesterase inhibitor that does not cause delayed neurotoxicity; [CAMEO] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

Banned in the EU for use as pesticide for plant protection; [eChemPortal: ESIS]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

5.4E-5 mm Hg

Lethal Concentration

LC50 (rat) > 2,200 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Reference Link

INCHEM JMPR: Fenitrothion - 2000

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: