Agent Name

Isobutyl alcohol

Alternative Name

Isobutanol

CAS Number

78-83-1

Formula

C4-H10-O

Major Category

Solvents

Synonyms

1-Hydroxymethylpropane; 1-Propanol, 2-methyl-; 2-Methyl propanol; 2-Methyl-1-propanol; 2-Methylpropyl alcohol; Alcool isobutylique [French]; Fermentation butyl alcohol; Isobutanol; Isobutyl alcohol; Isobutyl alcohol (natural); Isobutylalkohol [Czech]; Isopropylcarbinol; [ChemIDplus] UN1212

Category

Alcohols (<C12)

Description

Colorless, oily liquid with a sweet, musty odor; [NIOSH]

Sources/Uses

Used as solvent in lacquers, paint removers, and liquid chromatography; used in organic synthesis; [ACGIH]

Comments

In mice, 6400 ppm produces narcosis, but not death. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

PEL (OSHA)

100 ppm

MAK

100 ppm

IDLH (NIOSH)

1600 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty [1963] that 2 of 6 rats died when exposed for 4 hours to 8,000 ppm [Smyth et al. 1954]. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

10.5 mm Hg

Odor Threshold Low

0.66 ppm

Odor Threshold High

40 ppm

RD50

1818 ppm

Lethal Concentration

LCLo (rat) = 8,000 ppm/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 3.6 ppm); Flash point = 82 deg F;

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: