Agent Name

Isopropyl acetate

CAS Number

108-21-4

Formula

C5-H10-O2

Major Category

Solvents

Synonyms

1-Methylethyl acetate; 2-Acetoxypropane; 2-Propyl acetate; Acetate d'isopropyle [French]; Acetic Acid, isopropyl ester; Acetic acid, 1-methylethyl ester; Isopropile (acetato di) [Italian]; Isopropyl (acetate d') [French]; Isopropyl acetate; Isopropyl ethanoate; Isopropylacetaat [Dutch]; Isopropylacetat [German]; Isopropyle (acetate d') [French]; Isopropylester kyseliny octove [Czech]; Paracetat; [ChemIDplus] UN1220

Category

Esters (<C12)

Description

Colorless liquid with a fruity odor; [NIOSH]

Sources/Uses

Used as a solvent and flavoring agent; [ACGIH] Solvent uses include nitrocellulose, resins, paints, lacquers, inks, insecticides, and perfumes; [Hawley]

Comments

A skin, eye, and respiratory tract irritant; Inhalation of high concentrations far above the OEL can cause CNS depression; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

100 ppm

STEL (ACGIH)

200 ppm

PEL (OSHA)

250 ppm

MAK

100 ppm

IDLH (NIOSH)

1800 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1970] report that a 4hour exposure to 16,000 ppm killed 1 of 6 rats. . . . Other animal data: It has been stated that isopropyl acetate is comparable in toxicity to ethyl acetate and npropyl acetate [ACGIH 1991]. Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

60.4 mm Hg

Odor Threshold Low

0.5 ppm

Odor Threshold High

34 ppm

Lethal Concentration

LC50 (rat) = 50,600 mg/m3/8H

Explanatory Notes

IDLH = 10% LEL; Detection odor threshold from AIHA (mean = 4.1 ppm); Flash point = 2 deg C; See "2017 Notice of Intended Changes." [TLVs and BEIs]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: