Agent Name

Isopropyl alcohol

Alternative Name

2-Propanol

CAS Number

67-63-0

Formula

C3-H8-O

Major Category

Solvents

Synonyms

1-Methylethanol; 1-Methylethyl alcohol; 2-Hydroxypropane; 2-Propanol; 2-Propyl alcohol; Alcojel; Alcolo; Alcool isopropilico [Italian]; Alcool isopropylique [French]; Alcosolve; Alcosolve 2; Alkolave; Arquad DMCB; Avantin; Avantine; Combi-schutz; Dimethylcarbinol; Hartosol; Imsol A; Iso-propylalkohol [German]; Isohol; Isopropanol; Isopropyl alcohol; Isopropyl alcohol, rubbing; Lavacol; Lutosol; Petrohol; Propol; Spectrar; Sterisol hand disinfectant; Takineocol; Visco 1152; i-Propanol [German]; i-Propyl alcohol; i-Propylalkohol [German]; n-Propan-2-ol; sec-Propyl alcohol; [ChemIDplus] UN1219; UN1993

Category

Alcohols (<C12)

Description

Colorless liquid with the odor of rubbing alcohol; [NIOSH]

Sources/Uses

Used as a fuel antifreeze and an intermediate in the synthesis of organic chemicals; also used as a solvent for oils, resins, cosmetics, and many other household products; [ACGIH] Used as a disinfectant; [www.healthcouncil.nl]

Comments

Isopropyl alcohol causes narcosis in acute animal studies. [ACGIH] Isopropyl alcohol is not hepatotoxic in experimental animal studies or in human exposures. [Zimmerman, p. 367] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
BEI

Acetone in urine = 40 mg/L at end of shift at end of work week;

Skin Designation (ACGIH)

No

TLV (ACGIH)

200 ppm

STEL (ACGIH)

400 ppm

PEL (OSHA)

400 ppm

MAK

200 ppm

IDLH (NIOSH)

2000 ppm

Excerpts from Documentation for IDLHs

Ten volunteers exposed for 3 to 5 minutes to 200, 400, or 800 ppm reported mild to moderate irritation of the eyes, nose, and throat at the two higher concentrations [Nelson et al. 1943].

Vapor Pressure

45.4 mm Hg

Odor Threshold Low

1 ppm

Odor Threshold High

610 ppm

RD50

17693 ppm

Lethal Concentration

LC50 (rat) = 16,000 ppm/8H

Explanatory Notes

IDLH = 10% LEL; Detection odor threshold from AIHA (mean = 43 ppm); Flash point = 12 deg C;

Half Life

Whole body: 6 hours; whole body for acetone, a metabolite: 22 hours; [TDR, p. 781]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: