Agent Name

Fluorescein

CAS Number

2321-07-5

Formula

C20-H12-O5

Major Category

Dyes

Synonyms

11712 Yellow; 3',6'-Dihydroxyfluoran; 3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'(9H)-xanthen)-3-one; 3,6-Dihydroxyspiro(xanthene-9,3'-phthalide); 3,6-Fluorandiol; 3H-Xanthen-3-one, 9-(o-carboxyphenyl)-6-hydroxy-; 9-(o-Carboxyphenyl)-6-hydroxy-3-isoxanthenone; 9-(o-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one; Benzoic acid, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-; Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-; C.I. 45350:1; C.I. Solvent Yellow 94; CI 45350:1; D and C Yellow No. 7; D+C Yellow No. 7; Fluoran, 3',6'-dihydroxy-; Fluorescein Red; Fluorescein acid; Fluoresceine; Hidacid fluorescein; Japan Yellow 201; Japan Yellow No. 201; Resorcinolphthalein; Soap Yellow F; Solvent Yellow 94; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3'6'-dihydroxy-; Yellow fluorescein; Zlut kysela 73 [Czech]; [ChemIDplus]

Category

Other Dyes

Description

Yellowish-red to red solid; [Merck Index] Orange powder; [MSDSonline]

Sources/Uses

Used as dye for cosmetics, cleansers, other household products, and vascular and ophthalmic diagnosis (may be in form of sodium salt); Used as water indicator (detect leaks, pollution sources, and for sea rescues), adsorption indicator, and dye intermediate; [HSDB] Used as analytical and clinical reagent; [Merck Index]

Comments

Has caused adverse reactions by IV injection including cardiac arrest, severe shock, and anaphylaxis; In 547 patients, about 10% had adverse responses with nausea frequent, vomiting infrequent, and urticaria rare; [HSDB] A positive prick skin test was reported in one patient; [eChemPortal: ERMA] An irritant; [MSDSonline]

Reference Link

PubMed: Anaphylaxis following intravenous fluorescein angiography in a vitreoretinal clinic: report of 4 cases.

Links to Other NLM Databases
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