Agent Name

Fluoroacetamide

CAS Number

640-19-7

Formula

C2-H4-F-N-O

Major Category

Pesticides

Synonyms

1081; 2-Fluoroacetamide; AFL 1081; Amid kyseliny fluoroctove [Czech]; Baran; Compound 1081; FAA; Fluorakil 100; Fluorkill; Fluoroacetic acid amide; Fluoroakil 100; Flutritex 1; Fussol; Megatox; Monofluoroacetamide; Navron; Yanock; Acetamide, 2-fluoro-; [ChemIDplus] UN2811

Category

Rodenticides

Description

Colorless or white solid; [HSDB] Fine faintly brown crystals; [MSDSonline]

Sources/Uses

Used as rodenticide and insecticide; [HSDB] Used as a rodenticide in the US and as pesticide in other countries; The only continued registration in the US after 1980 was for rat control in sewers with application by certified professionals and highly restricted; [EPA OHM/TADS]

Comments

Can be absorbed through skin; In animal experiments, toxic to the heart (fatal arrhythmias) and reproductive system; [ICSC] A testicular poison in animal studies; [HSDB] Probable oral lethal dose in humans is less than 5 mg/kg (less than 7 drops); Inhibits oxygen metabolism by cells; [CAMEO] Converted to fluoroacetic acid in vivo causing buildup of fluorocitric acid and inhibiting Krebs cycle; [UNEP] May cause irritation; Can be absorbed through skin; Metabolized to fluoroacetate (highly toxic); [MSDSonline] See "Sodium fluoroacetate."

Restricted

No longer registered with the EPA for use in the US; [HSDB] Banned in the EU for use as pesticide; [eChemPortal: ESIS] Use in Israel and Japan (insecticide for citrus) requires special permit from the government (as of 1991); [UNEP]

Exposure Assessment
Vapor Pressure

0.99 mm Hg

Lethal Concentration

LC50 (mice) = 550 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, organic, n.o.s."

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: