Agent Name

Formothion

CAS Number

2540-82-1

Formula

C6-H12-N-O4-P-S2

Major Category

Pesticides

Synonyms

2-Dimethoxyphosphinothioylthio-N-formyl-N-methylacetamide; Acetamide, N-formyl-2-mercapto-N-methyl-, S-ester with O,O-dimethyl phosphorodithioate; Aflix; Afliz; Afliz [Sandoz]; Anthio; Anthio 25; Antio; CP 53926; ENT 27,257; Formothion 25 EC; J-38; N-Formyl-N-methylcarbamoylmethyl O,O-dimethyl phosphorodithioate; O,O-Dimethyl S-(N-formyl-N-methylcarbamoylmethyl) phosphorodithioate; O,O-Dimethyl S-(N-methyl-N-formylcarbamoylmethyl)phosphorodithioate; O,O-Dimethyl dithiophosphorylacetic acid N-methyl-N-formylamide; O,O-Dimethyl phosphorodithioate N-formyl-2-mercapto-N-methylacetamide S-ester; O,O-Dimethyl phosphorodithioate S-ester with N-formyl-2-mercapto-N-methylacetamide; O,O-Dimethyl-S-(3-methyl-2,4-dioxo-3-aza-butyl)-dithiofosfaat [Dutch]; O,O-Dimethyl-S-(3-methyl-2,4-dioxo-3-aza-butyl)-dithiophosphat [German]; O,O-Dimethyl-S-(N-methyl-N-formyl-carbamoylmethyl)-dithiophosphat [German]; O,O-Dimetil-S-(N-formil-N-metil-carbamoil-metil)-ditiofosfato [Italian]; OMS-968; P 1; Phosphorodithioic acid, O,O-dimethyl ester, N-formyl-2-mercapto-N-methylacetamide S-ester; Phosphorodithioic acid, S-(2-(formylmethylamino)-2-oxoethyl) O,O-dimethyl ester; S 6900; S-(2-(Formylmethylamino)-2-oxoethyl) O,O-dimethyl phosphorodithioate; S-(2-(Formylmethylamino)-2-oxoethyl) O,O-dimethylphosphorodithioate; S-(Formyl(methyl)carbamoylmethyl) O,O-dimethyl phosphorodithioate; S-(N-Formyl-N-methylcarbamoylmethyl) O,O-dimethyl phosphorodithioate; S-(N-Formyl-N-methylcarbamoylmethyl) dimethyl phosphorothiolothionate; SAN 244 I; SAN 6913 I; SAN 7107 I; Sandoz S-6900; Spencer S-6900; Toprose; VEL 4284; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellow liquid; mp = 25 deg C; [Hawley] Pale yellow liquid or solid; mp = 25-26 deg C; [HSDB] Colorless to pale yellow liquid or solid; mp = 25-26 deg C; [MSDSonline]

Sources/Uses

Used as acaricide and systemic insecticide; [Merck Index] Not currently commercially produced in the US; Likely discontinued for pesticide use worldwide; [HSDB]

Comments

Not irritating to rabbit eyes; Effects in high dose animal studies include inhibition of cholinesterase activity, minor histological changes to liver and adrenal glands, functional changes of the liver, and hematological changes; No evidence of skin sensitization, increased tumor incidence, other neurotoxicity, nor developmental or teratogenic toxicity [HSDB] No significant adverse gross or histological changes or increase in tumor frequency observed in two year feeding studies with rats and dogs; [INCHEM JMPR]

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

8.48E-7 mm Hg

Lethal Concentration

LC50 (rat) = 4,500 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: