Agent Name

Fumonisin B1

CAS Number

116355-83-0

Formula

C34-H59-N-O15

Major Category

Biological Agents

Synonyms

Macrofusine; 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl) ester; [ChemIDplus]

Category

Mycotoxins

Description

White hygroscopic solid; [HSDB] Light brownish-yellow solid; [MSDSonline]

Sources/Uses

Most common member of a family of mycotoxins produced by Fusarium moniliforme, a common corn mold; [Merck Index]

Comments

Causes abnormal liver function tests after subcutaneous doses in mice; [RTECS] Causes increased liver cancer in rats; [IARC] Interferes with sphingolipid metabolism in animals causing leukoencephalomalacia in horses and rabbits, pulmonary edema and hydrothorax in swine, and hepatotoxicity and liver cancer in rats; It is probably linked with esophageal cancer in humans exposed to moldy corn meal and grits; [Reference #2]

Reference Link

INCHEM: Fumonisin B1 (EHC 219 - 2000)

Exposure Assessment
Reference Link

PubMed Full-Text: Mycotoxins

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.