Agent Name

Fusarenon X

CAS Number

23255-69-8

Formula

C17-H22-O8

Major Category

Biological Agents

Synonyms

12,13-Epoxy-3-alpha,4-beta,7-alpha,15-tetrahydroxytrichothec-9-en-8-one 4-acetate; 3,7,15-Trihydroxy-4-acetoxy-8-oxo-12,13-epoxy-delta(sup 9)-trichothecene; 3alpha,7alpha,15-Trihydroxy-4beta-acetoxy-12,13-epoxytrichothec-9-en-8-one; 4-Acetyloxy-12,13-epoxy-3,7,15-trihydroxy-(3-alpha,4-beta,7-alpha)-trichothec-9-en-8-one; Fusarenon; Fusarenone X; Nivalenol monoacetate; Nivalenol-4-O-acetate; Trichothec-9-en-8-one, 12,13-epoxy-3alpha,4beta,7alpha,15-tetrahydroxy-, 4-acetate; Trichothec-9-en-8-one, 4-(acetyloxy)-12,13-epoxy-3,7,15-trihydroxy-, (3alpha,4beta,7alpha)-; [ChemIDplus]

Category

Mycotoxins

Description

Transparent solid; [HSDB]

Sources/Uses

A mycotoxin produced by Fusarium nivale; [ChemIDplus] Zearalenone, deoxynivalenol, and fusarenon X are mycotoxins produced by three Fusarium species (F. graminearum, F. culmorum, and F. crookwellense) that grow on wheat, barley, and maize in humid conditions. [IARC] Human exposure to Fusarenon X is rare; [IARC]

Comments

Trichothecene mycotoxins causes bone marrow suppression, leukopenia, immunosuppression, and secondary sepsis; [HSDB] Causes diarrhea and muscle weakness at lethal doses fed to rats; Causes hepatocellular necrosis in cats after subcutaneous doses; [RTECS] LD50 (mice) = 3-5 mg/kg by all routes; Causes cellular destruction in rapidly dividing cells of the GI tract, thymus, lymph nodes, spleen, bone marrow, ovaries, and testes; Exposed animals have diarrhea, food refusal, and vomiting; Highly irritating to the skin of animals causing necrosis of hair follicles and dermis; [IARC] See "T-2 toxin."

Reference Link

PubMed Full-Text: Mycotoxins

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

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Chemical Information

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