Agent Name

Glycyrrhizin

CAS Number

1405-86-3

Formula

C42-H62-O16

Major Category

Biological Agents

Synonyms

(3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1- 7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1-7-glucopyranuronosyl-; 18-beta-Glycyrrhizic acid; 20beta-Carboxy-11-oxo-30-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; Glycyron; Glycyrrhetinic acid glycoside; Glycyrrhizic acid; Glycyrrhizinic acid; Liquorice; Rizinsan K2 A2 (free acid); alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-; [ChemIDplus]

Category

Plant Toxins

Description

Solid with intensely sweet taste; [Merck Index] Crystalline plates or prisms; [MSDSonline]

Sources/Uses

The active principle extracted from licorice root; Used as a humectant in tobacco and as a flavor in confectionery and pharmaceuticals; [Hawley]

Comments

Emergency treatment: "Liquorice"; "Hypokalemia, hypernatremia, and water retention are primary problems associated with chronic liquorice ingestion." Glycyrrhizin is the major active compound (triterpene glycoside) in licorice root. It has been used as an herbal remedy for ulcers, inflammation, and viral infections. After ingestion and hydrolysis, the compound inhibits an enzyme that results in increased serum cortisol levels. [Haddad, p. 485] No adverse effects in the majority of adults expected at doses <100 mg/day; A high intake of liquorice confectionery or herbal tea may exceed 100 mg/day; [JECFA]

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