Agent Name

Grayanotoxin I

CAS Number

4720-09-6

Formula

C22-H36-O7

Major Category

Biological Agents

Synonyms

7,9a-Methano-9aH-cyclopenta(b)heptalene-2,4,8,11,11a,12(1H)-hexol-, dodecahydro-1,1,4,8-tetramethyl-, 12-acetate, (2S,3aS,4R,4aR,7R,8R,9aS,11R,11aR,12R)-; Acetylandromedol; Andromedotoxin; Asebotoxin; G-I; GTX-I; Grayanotoxane-3,5,6,10,14,16-hexol 14-acetate; Perhydro-2beta,4alpha,8alpha,11beta,11abeta-pentahydroxy-1,1,4,8-tetramethyl-7,9a-methano-9aalphaH-cyclopenta(b)heptalen-12beta-yl acetat; Rhodotoxin; Rhodotoxine; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index]

Sources/Uses

Toxic diterpenoid found in the leaves of different Rhododendron, Kalmia, and Leucothoe species and in rhododendron flower honey; [Merck Index] Used for physiological research; [HSDB] Toxin found in azalea, heath, lily-of-the-valley bush, mountain laurel, and rhododendron; [Olson, p. 336-47]

Comments

Emergency treatment: "Plants- Grayanotoxins"; Prognosis is excellent with supportive care and treatment of hypotension and dysrhythmias; Toxicity may occur after eating 10 azalea blossoms or 50-75 ml of honey made by bees eating nectar of rhododendrons or other plants of the Ericaceae family; [HSDB] Symptoms after ingestion include paresthesias, vomiting, hypotension, bradycardia, seizures, and coma; [Olson, p. 335]

Exposure Assessment
Vapor Pressure

2.3E-14 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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