Agent Name

N,N'-Bis(2-methylphenyl)guanidine

CAS Number

97-39-2

Formula

C15-H17-N3

Major Category

Plastics & Rubber

Synonyms

1,3-Ditolylguanidine; 1,3-Bis(o-tolyl)guanidine; 1,3-Di-o-tolyguanidine; 1,3-Di-o-tolylguanidine; Akrochem DOTG; CNS 1001; DOTG; DOTG accelerator; DTG; Di-o-tolylguanidine; Diorthotolylguanidine; Eveite DOTG; Guanidine, 1,3-di(2-tolyl)-; Guanidine, 1,3-di-o-tolyl-; Guanidine, N,N'-bis(2-methylphenyl)-; N,N'-Di-o-tolueylguanidine; N,N'-Di-o-tolylguanidine; Nocceler DT; Sanceler DT; Soxinol DT; Vulcafor DOTG; Vulkacit DOTG; Vulkacit DOTG/C; Vulkacite DOTG; [ChemIDplus]

Category

Rubber Additives

Description

White solid; [Hawley] Grey or white powder; [MSDSonline]

Sources/Uses

Used as a rubber accelerator; [Hawley] Degraded during the vulcanization process, so consumers not likely to have significant exposure; [Reference #1]

Comments

A selective ligand for the sigma site in the mammalian CNS--high parenteral doses in rodents cause behavioral effects; [Reference #1] Presumed to be irritating to eye mucous membranes; [HSDB] Oral LD50 (rat) = 500 mg/kg; Oral LDLo (unspecified mammal) = 120 mg/kg (Effects included somnolence, dyspnea, and cyanosis.) [ChemIDplus] An eye irritant; [eChemPortal: ERMA] May cause irritation; [MSDSonline]

Reference Link

OECD SIDS: 1,3-Di-o-tolylguanidine - 2007

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.