Agent Name

Helenalin

CAS Number

6754-13-8

Formula

C15-H18-O4

Major Category

Biological Agents

Synonyms

(3aS)-3,3aalpha,4alpha,4a,7aalpha,8,9,9aalpha-Octahydro-4-hydroxy-4abeta,8 alpha-dimethyl-3-methyleneazuleno(6,5-b)-furan-2,5-dione; 6alpha,8beta-Dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oic acid 12,8-lactone; Ambrosa-2,11(13)-dien-12-oic acid, 6alpha,8beta-dihydroxy-4-oxo-, 12,8-lactone; Azuleno(6,5-b)furan-2,5-dione, 3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-, (3aS-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-; PF 56; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index] White solid; [MSDSonline]

Sources/Uses

Extremely toxic sesquiterpene lactone found in Helenium microcephalum (smallhead sneezeweed); [HSDB]

Comments

Causes seizures at lethal doses in mice; Intraperitoneal LD50 (mouse) = 10 mg/kg; [RTECS] Especially toxic in flowering stage; may cause paralysis of voluntary and cardiac musculature and fatal gastroenteritis; Emergency treatment: "Plants- sesquiterpene lactones"; Sesquiterpene lactones are in many plants. They cause toxicity mainly in livestock that eat the plants. Human poisoning cases are extremely rare. Possible symptoms after ingestion include irritation of mucous membranes, dyspnea, pulmonary hemorrhage, tremors, seizures, abdominal pain, and liver injury. [HSDB] Sesquiterpene lactones are a common cause of allergic dermatitis in florists. See "Sesquiterpene lactones."

Exposure Assessment
Vapor Pressure

4.69E-9 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: