Agent Name

Methyl 2-cyanoacrylate

CAS Number

137-05-3

Formula

C5-H5-N-O2

Major Category

Plastics & Rubber

Synonyms

2-Cyano-2-propenoic acid methyl ester; 2-Cyanoacrylic acid, methyl ester; 2-Propenoic acid, 2-cyano-, methyl ester; Acrylic acid, 2-cyano-, methyl ester; Adhere; Borden Ad/Here; Cemedine 3000; Cemedine 3000 Type II; Coapt; Cyanolit; Eastman 910; Eastman 910 adhesive; Eastman 910 monomer; Krazy-Glue; Mecrilat; Mecrilato [INN-Spanish]; Mecrilatum [INN-Latin]; Mecrylate; Methyl 2-cyano-2-propenoate; Methyl cyanoacrylate; alpha-Cyanoacrylic acid methyl ester; [ChemIDplus]

Category

(Meth)acrylates

Description

Clear, colorless liquid with irritating, acrid odor; [ACGIH]

Sources/Uses

Occupational asthma reported in workers using adhesives; [Malo]

Comments

Asthma: Occupational asthma due to methyl methacrylate and cyanoacrylate. [Lozewicz S et al. Thorax 1985 Nov;40(11):836-9]; A potential skin sensitizer; [ICSC] DSEN and RSEN notations recommended; [ACGIH]

Reference Link

Occupational asthma due to methyl methacrylate and cyanoacrylates

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.2 ppm

STEL (ACGIH)

1 ppm

MAK

2 ppm

Vapor Pressure

0.2 mm Hg

Odor Threshold Low

1 ppm

Odor Threshold High

3 ppm

Lethal Concentration

LC50 (rat) = 101 ppm/6h

Explanatory Notes

Odor thresholds from ACGIH;

Reference Link

High eosinophil levels and poor evolution in occupational asthma due to cyanoacrylate exposure.

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: