Agent Name

Hexachloroacetone

CAS Number

116-16-5

Formula

C3-Cl6-O

Major Category

Other Classes

Synonyms

1,1,1,3,3,3-Hexachloro-2-propanone; 1,1,1,3,3,3-Hexachloropropanone; 2-Propanone, 1,1,1,3,3,3-hexachloro-; 2-Propanone, hexachloro-; Acetone, hexachloro-; Bis(trichloromethyl) ketone; GC-1106; HCA; HCA (VAN); HCA weedkiller; Hexachloro-2-propanone; Hexachloropropanone; Kureha HCA; Perchloro-2-propanone; Perchloroacetone; [ChemIDplus] UN2661

Category

Halogenated Ketones

Description

Yellow liquid; [Hawley]

Sources/Uses

Used as reagent for N-trichloroacetylation of dipeptides, to produce chloroform, and formerly as a herbicide and pre-harvest desiccant on alfalfa seed crops; [HSDB]

Comments

Highly irritating; Produces phosgene when heated; [Hawley] A skin and mucous membrane irritant; A mild lachrymator; Oral LD50 (rat) = 1550 mg/kg; In animal studies, caused pulmonary edema after inhalation and liver and kidney injury after ingestion; Can cause burns of skin and eyes; [HSDB] Oral TDLo (rat) = 450.8 mg/kg (1-14D preg) for maternal effects (oogenesis); [RTECS] Contact with molten substance may cause severe burns; [CAMEO] An irritant; Effects in high-dose animal studies include pulmonary edema; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.12 mm Hg

Lethal Concentration

LC50 (rat) = 360 ppm/6h

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Processes

Industrial Processes with risk of exposure: