Agent Name

Hexachlorodibenzo-p-dioxin

CAS Number

34465-46-8

Formula

C12-H2-Cl6-O2

Major Category

Other Classes

Synonyms

HCDD; Hexachlorodibenzo-4-dioxin; Dibenzo(b,e)(1,4)dioxin, hexachloro-; Dibenzo-p-dioxin, hexachloro-; Hexachlorodibenzodioxin; [ChemIDplus]

Category

Halogenated Polyaromatics

Sources/Uses

Found as impurity in pesticides and pentachlorophenol (wood preservative); Produced from combustion of coal, refuse, wood, cigarettes, and materials containing PVC; Also found in municipal waste water and effluents from pulp and paper manufacture (when chlorine used for bleaching); Not commercially produced; [HSDB]

Comments

IARC classification is for polychlorinated dibenzo-para-dioxins other than 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); Polychlorodibenzodioxins have caused chloracne in humans; Occupational exposure may occur from contact with contaminated compounds (i.e. pesticides and pentachlorophenol), in metal reclamation, or during manufacture of chlorophenols; 1,2,3,4,7,8- isomer oral LD50 (rat) = 0.887 mg/kg; Effects in high-dose feeding studies with rats include hemorrhage, anemia, wasting syndrome, and changes in liver enzyme activity; Some evidence of increase in tumor frequency and teratogenicity; [HSDB] Significant exposure more likely through breast milk than transplacentally; Similar toxicity to TCDD, but less potent; [REPROTOX]

Exposure Assessment
Vapor Pressure

4.4E-11 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Not Classifiable

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Health Studies

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: