Agent Name

Hexamethyldisiloxane

CAS Number

107-46-0

Formula

C6-H18-O-Si2

Major Category

Metals

Synonyms

Belsil DM 0.65; Bis(trimethylsilyl)ether; Bis(trimethylsilyl)oxide; Bis-trimethylsilyl oxide; Bistrimethylsilyl ether; Disiloxane, hexamethyl-; Fluka AG; HMS; Hexamethyl disiloxane; KF 96L; OS 10; Oxybis(trimethylsilane); SWS-F 221; Silane, oxybis(trimethyl-; [ChemIDplus]

Category

Metalloid Compounds (Silicon)

Description

Liquid; [HSDB] Colorless liquid; [MSDSonline]

Sources/Uses

Used to make silicone fluids, elastomers, octamethylcyclotetrasiloxane, and fluorosilicone oils; Also used in cosmetics and in photolithography applications (adhesion promoter/priming agent); [HSDB]

Comments

An eye irritant; Oral LD50 (rat) = >5000 mg/kg; [HSDB] In a 28-day feeding study of rats, 8 mg/kg/day was the no toxic effect level; Food consumption was decreased and changes were seen in the liver and blood cells in animals fed 640 mg/kg/day; [TSCA Sub-Acute Oral Toxicity Study in Rats] May cause irritation; [MSDSonline]

Exposure Assessment
Vapor Pressure

42 mm Hg

Lethal Concentration

LC50 (rat) = 15,956 ppm/4h

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Other Information

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