Agent Name

Methylal

Alternative Name

Dimethoxymethane

CAS Number

109-87-5

Formula

C3-H8-O2

Major Category

Other Classes

Synonyms

2,4-Dioxapentane; Anesthenyl; Bis(methoxy)methane; Dimethoxymethane; Dimethyl formal; Formal; Formaldehyde dimethyl acetal; Formaldehyde dimethylacetal; Formaldehyde methyl ketal; Methane, dimethoxy-; Methoxymethyl methyl ether; Methylene dimethyl ether; Metylal [Polish]; [ChemIDplus] UN1234

Category

Acetals

Description

Colorless liquid with a chloroform-like odor; [NIOSH]

Sources/Uses

Used as a solvent for adhesives and coatings, a fuel, and an intermediate for other organic compounds; [ACGIH] Has been used as an anesthetic; [HSDB]

Comments

Animal inhalation studies: anesthesia and damage to the liver and other organs; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

1000 ppm

PEL (OSHA)

1000 ppm

MAK

1000 ppm

IDLH (NIOSH)

2200 ppm

Excerpts from Documentation for IDLHs

Other animal data: In one study, the "no effect" levels were determined to be 2,810 and 8,450 ppm in rats and guinea pigs, respectively [Price et al. 1978]. Fifteen 7hour exposures to 11,000 ppm caused only minor irritation in 50 mice [Weaver et al. 1951]. . . .Human data: Methylal has been used as an anesthetic in surgery [ACGIH 1991].

Vapor Pressure

398 mm Hg

Lethal Concentration

LC50 (mice) = 57,000 mg/m3/7H

Explanatory Notes

IDLH = 10% LEL; Flash point = -32 deg C;

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: