Agent Name

Hypoglycine A

CAS Number

156-56-9

Formula

C7-H11-N-O2

Major Category

Biological Agents

Synonyms

2-Amino-4,5-methylenehex-5-enoic acid; 2-Methylenecyclopropanealanine; 2-Methylenecyclopropanylalanine; Cyclopropanealanine, 2-methylene, L-; Cyclopropanealanine, 2-methylene-; Cyclopropanepropanoic acid, alpha-amino-2-methylene-; Cyclopropanepropionic acid, alpha-amino-2-methylene-, L-(+)-; Hypoglycin; Hypoglycin A; Hypoglycine; L-alpha-Amino-beta-methylenecyclopropanepropionic acid; alpha-Amino-2-methylenecyclopropanepropanoic acid; alpha-Amino-2-methylenecyclopropanepropionic acid; alpha-Amino-beta-(2-methylenecyclopropyl)propionic acid; alpha-Aminomethylenecyclopropanepropionic acid; beta-(Methylenecyclopropyl)alanine; beta-(Methylenecyclopropyl)alanine (VAN); [ChemIDplus]

Category

Plant Toxins

Description

Yellow solid; [Merck Index]

Sources/Uses

Hypoglycemia-inducing component of the akee plant (Blighia sapida); [Merck Index] A water-soluble liver toxin found in the seeds, pods, and unripe fruit of the ackee plant; Ackee is the national fruit of Jamaica, where it is associated with Jamaican vomiting sickness or Toxic Hypoglycemic Syndrome (THS); [HSDB]

Comments

Emergency treatment: "Plants- ackee"; Most poisonings occurred before 1955 in Jamaica or the West Indies; There were fatal cases in preschool children. Severe hypoglycemia below 29 mg/dl is followed by depletion of liver glycogen. Hepatitis may develop. [HSDB] Hypoglycin A & B are hypoglycemic agents from the unripe fruit of the akee plant; Hypoglycemia and vomiting precede the CNS symptoms of seizures and coma; [Ford, p. 919]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.