Agent Name

MBOCA

Alternative Name

4,4'-Methylene bis (2-chloroaniline)

CAS Number

101-14-4

Formula

C13-H12-Cl2-N2

Major Category

Plastics & Rubber

Synonyms

4,4'-Methylene bis (2-chloroaniline); 3,3'-Dichlor-4,4'-diaminodiphenylmethan [German]; 3,3'-Dichloro-4,4'-diaminodifenilmetano [Italian]; 3,3'-Dichloro-4,4'-diaminodiphenylmethane; 3,3'-Dicloro-4,4'-diaminodifenilmetano [Italian]; 4,4'-Diamino-3,3'-dichlorodiphenylmethane; 4,4'-Methylene(bis)-chloroaniline; 4,4'-Methylenebis(2-chloroaniline); 4,4'-Methylenebis(o-chloroaniline); 4,4'-Methylenebis-2-chlorobenzenamine; 4,4-Metilene-bis-o-cloroanilina [Italian]; Aniline, 4,4'-methylenebis(2-chloro-; Benzenamine, 4,4'-methylenebis(2-chloro-; Bis amine; Bis(3-chloro-4-aminophenyl)methane; Bis(4-amino-3-chlorophenyl)methane; Bis-amine A; Bisamine; Bisamine S; CL-Mda; Cuamine M; Cuamine MT; Curalin M; Curene 442; Cyanaset; Dacpm; Di(-4-amino-3-chlorophenyl)methane; Di-(4-amino-3-clorofenil)metano [Italian]; Diamet Kh;LD 813; MOCA; MOCA (curing agent); Mboca; Methylene 4,4'-bis(o-chloroaniline); Methylene-bis-orthochloroaniline; Methylenebis(3-chloro-4-aminobenzene); Methylenebis(chloroaniline); Millionate M; Quodorole; p,p'-Methylenebis(alpha-chloroaniline); p,p'-Methylenebis(o-chloroaniline); p,p'-Methylenebis(ortho-chloroaniline); [ChemIDplus]

Category

Curing Agents (Aromatic)

Description

Tan-colored pellets or flakes with a faint, amine-like odor; [NIOSH]

Sources/Uses

Used as a curing agent for polyurethanes and epoxy resins; [ACGIH]

Comments

Causes bladder cancer and methemoglobinemia in animal toxicology studies; Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Signs of poisoning include hematuria and methemoglobinemia; [Merck Index # 6059] "The genotoxicity of 4,4'-methylenebis(2-chlorobenzenamine) is well documented and its toxicological profile is similar to that of orthotoluidine, thus indicating a common mode of action. 4,4'-methylenebis(2-chlorobenzenamine) has been shown to interact with DNA to form adducts in urothelial cells, and with haemoglobin to form adducts in the blood of workers exposed to this compound." [Reference #1]

Reference Link

IARC 2012: MBOCA

Exposure Assessment
BEI

Total MBOCA in urine = screen at end of shift;

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.01 ppm

Vapor Pressure

2.86E-7 mm Hg

Half Life

Urine: 23 hours to several days; [TDR, p. 856]

Reference Link

ATSDR - ToxFAQs - 4,4'-Methylenebis(2-chloroaniline) (MBOCA)

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Secondary

Anemia

Anemia, Hemolytic

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Suspected Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: