Agent Name

Indocyanine green

CAS Number

3599-32-4

Formula

C43-H48-N2-O6-S2.Na

Major Category

Dyes

Synonyms

1H-Benz(e)indolium, 2-(7-(1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz(e)indol-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, inner salt, sodium salt; 2-(7-(1,1-Dimethyl-3-(4-sulfobutyl)benz(e)indolin-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indolium hydroxide, inner salt, sodium salt; 2-(7-(1,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)benz(e)indolin-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indoliumhydroxide inner sodium salt; Anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'-dibenzoindotricarbocyanine hydroxide inner salt sodium salt; Cardio-Green; Fox Green; HWD Indocyanine Green; IC-Green; ICG; IR 125; Indocyanine Green; NK 1611; Natrium 4-(2-(7-(2,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz(e)indol-2-yliden)-1,3,5-heptatrienyl)-1,1-dimethyl-1H-benz(e)indol-3-ol)butan-1-sulfonat; Ujoviridin; Wofaverdin; [ChemIDplus]

Category

Carbocyanine Dyes

Description

Dark green, blue-green, olive brown, dark blue, or black solid; Solutions are deep emerald-green; [HSDB]

Sources/Uses

Tricarbocyanine dye that absorbs infrared radiation; Used for infrared photography, Wratten filter production, and blood volume, cardiac output, and hepatic function diagnostics; [Merck Index]

Comments

Very low incidence of side effects when injected into the veins and arteries of patients during medical testing; "May cause transient elevation in serum unconjugated bilirubin, probably due to competition between dye & bilirubin for biliary excretion." In digital videoangiography performed on 1226 consecutive patients, adverse reactions (i.e. allergic or anaphylactic) were noted in eight patients, only one of which was severe but not fatal; It contains a small amount of sodium iodide and should be used with caution in patients allergic to iodides; [HSDB] An irritant; [MSDSonline]

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