Agent Name

Monomethyl aniline

CAS Number

100-61-8

Formula

C7-H9-N

Major Category

Nitrogen Compounds

Synonyms

(Methylamino)benzene; Aniline, N-methyl-; Benzeneamine, N-methyl-; Methylphenylamine; Monomethylaniline; N-Methylaminobenzene; N-Methylbenzenamine; N-Methylphenylamine; N-Monomethylaniline; N-Phenylmethylamine; [ChemIDplus] UN2294

Category

Amines, Aromatic

Description

Yellow to light-brown liquid with a weak, ammonia-like odor; [NIOSH]

Sources/Uses

Used as a solvent and in organic synthesis; [ACGIH] Solvent for organic reactions and for nitrocellulose; [HSDB]

Comments

Methemoglobinemia and liver injury occur in animals exposed to high concentrations over a period of weeks and months. There are no reports of human poisoning by monomethyl aniline. Listed in table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] Can induce methemoglobinemia; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 ppm

PEL (OSHA)

2 ppm

MAK

0.5 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that a dog survived 50 sevenhour exposures to 86 ppm [Treon et al. 1949].

Vapor Pressure

0.3 mm Hg

Odor Threshold Low

1.6 ppm

Odor Threshold High

2 ppm

Explanatory Notes

Odor threshold from AIHA; Flash point = 175 deg F;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: