Agent Name

Isazofos

CAS Number

42509-80-8

Formula

C9-H17-Cl-N3-O3-P-S

Major Category

Pesticides

Synonyms

A-12223; Brace; CGA-12223; Ciba 12223; Isazophos; Miral; Miral 10 G; O-(5-Chloro-1-(1-methylethyl)-1H-1,2,4-triazol-3-yl) O,O-diethyl phosphorothioate; O-(5-Chloro-1-isopropyl-1H-1,2,4-triazol-3-yl) O,O-diethylphosphorothioate; O-5-Chloro-1-isopropyl-1H-1,2,4-triazol-3-yl O,O-diethyl phosphorothioate; Triumph; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellow or amber liquid; [HSDB]

Sources/Uses

Used as insecticide for turf, maize, rice, and other crops; Also used as soil nematicide for bananas, citrus, and other annual crops; [HSDB]

Comments

Caused inhibition of cholinesterase activity but no gross or histopathological changes observed in long term feeding studies with rats and dogs; No evidence of increase in tumor frequency in long term feeding studies with rats; Caused developmental toxicity in rats at dose levels maternally toxic; No evidence of delayed neurotoxicity in oral studies with birds; No evidence of any mutagenic effects from the California EPA (2003); Marked increase in spontaneous mutation frequency observed with Salmonella and increase in mitotic indices and chromosome aberrations seen in bone marrow cells of mice (Mutation Research in Amsterdam 1998); [HSDB]

Restricted

No longer registered as a pesticide for use in the US; [HSDB]

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

8.7E-5 mm Hg

Lethal Concentration

LC50 (rat) = 103 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: