Agent Name

p-Nitroaniline

CAS Number

100-01-6

Formula

C6-H6-N2-O2

Major Category

Nitrogen Compounds

Synonyms

1-Amino-4-nitrobenzene; 4-Nitraniline; 4-Nitroaniline; 4-Nitrobenzenamine; Aniline, 4-nitro-; Aniline, p-nitro-; Azoamine Red ZH; Azofix Red GG Salt; Azoic Diazo Component 37; Benzenamine, 4-nitro-; C.I. 37035; C.I. Azoic Diazo Component 37; C.I. Developer 17; CI 37035; CI Azoic Diazo Component 37; CI Developer 17; Developer P; Devol Red GG; Diazo Fast Red GG; Fast Red 2G Base; Fast Red 2G Salt; Fast Red Base 2J; Fast Red Base GG; Fast Red GG Base; Fast Red GG Salt; Fast Red MP Base; Fast Red P Base; Fast Red P Salt; Fast Red Salt 2J; Fast Red Salt GG; Naphtoelan Red GG Base; Nitrazol CF Extra; PNA; PNA (VAN); Red 2G Base; Shinnippon Fast Red GG Base; p-Aminonitrobenzene; p-Nitraniline; p-Nitroanilina [Polish]; p-Nitroaniline; p-Nitrophenylamine; para-Aminonitrobenzene; para-Nitroaniline; [ChemIDplus] UN1661

Category

Nitroanilines

Description

Bright yellow, crystalline powder with a slight ammonia-like odor; [NIOSH]

Sources/Uses

Used in the production of dyes, antioxidants, gasoline gum inhibitors, and corrosion inhibitors; [ACGIH]

Comments

Can cause severe methemoglobinemia in the workplace; Chronic exposure can cause anemia, jaundice, and liver injury; Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A mild eye irritant; May induce methemoglobinemia; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

3 mg/m3

PEL (OSHA)

6 mg/m3

IDLH (NIOSH)

300 mg/m3

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH (300 mg/m3 or 50 ppm) is based on an analogy with aniline and the statement by AIHA [1955] that 50 to 100 ppm aniline can probably be tolerated for 1 hour. Although the IDLH chosen for aniline was 100 ppm, the IDLH of 50 ppm (300 mg/m3) chosen for pnitroaniline is reasonable because Von Oettingen [1941] stated that pnitroaniline is more toxic than aniline. . . . Human data: None relevant for use in determining the revised IDLH

Vapor Pressure

0.004 mm Hg

Explanatory Notes

Flash point = 199 deg C;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: