Agent Name

Isofenphos

CAS Number

25311-71-1

Formula

C15-H24-N-O4-P-S

Major Category

Pesticides

Synonyms

1-Methylethyl-2-((ethoxy((1-methylethyl)amino)phosphinothioyl)oxy) benzoate; 2-((Ethoxy((1-methylethyl)amino)phosphinothioyl)oxy)benzoic acid 1-methylethyl ester; 2-(O-Aethyl-N-isopropylamidothiophosphoryloxy)-benzosaeure-isopropylester [German]; 40 SD; Amaze; BAY-92114; BAY-SRA-12869; Discus; Isophenphos [ISO-French]; Isopropyl O-(ethoxy(isopropylamino)phosphinothioyl)salicylate; Isopropyl O-(ethoxy-N-isopropylamino(thiophosphoryl))salicylate; Isopropyl salicylate O-ester with O-ethyl isopropylphosphoramidothioate (8CI); Isopropyl salicylate O-ester with O-ethylisopropylphosphoramidothioate; Isopropyl salicylate ester of O-ethyl isopropylphosphoramidothioate; LE-Mat; O-Ethyl O-(2-isopropoxycarbonyl)phenyl isopropylphosphoramidothioate; Oftanol; Phosphoramidothioic acid, isopropyl-, O-ethyl O-(2-isopropoxycarbonylphenyl) ester; Pyrfon; SRA 12869; SRA 128691; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Liquid; [Merck Index] Colorless liquid; [CAMEO]

Sources/Uses

Used as soil insecticide for turf and ornamentals; [HSDB] Approximately 60% of the US consumption was used on golf courses; [Reference #1]

Comments

Not irritating to skin and mildly irritating to eyes of rabbits; No evidence of delayed neuropathy in intramuscular injection study with hens; [HSDB] No developmental effects in studies with rats at doses that caused cholinesterase inhibition in mothers; No available studies on human reproductive effects or effects on lactation; [REPROTOX] No clinical or histopathological evidence of delayed neurotoxicity in three studies with hens (at doses up to 2 mg/kg bw for 90 days and single oral doses up to 74 mg/kg bw after antidotal treatment); Observations of delayed neurotoxic effects in one study with hens two weeks following (dosage of 100 mg/kg bw achieved with antidotal treatments); [Reference #2]

Restricted

Voluntarily cancelled by the sole US registrant in 1999; All tolerances revoked; [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

3.0E-6 mm Hg

Lethal Concentration

LC50 (rat) = 144 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Reference Link

INCHEM JMPR: Isofenphos - 1982

Adverse Effects
Neurotoxin

Motor Neuropathy

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: