Agent Name

Acrylamide

CAS Number

79-06-1

Formula

C3-H5-N-O

Major Category

Plastics & Rubber

Synonyms

Acrylamide monomer; Acrylic amide; Propenamide; 2-Propenamide; [NIOSH]

Category

Other Monomers

Description

White crystalline, odorless solid; [NIOSH]

Sources/Uses

Used as a polymer or copolymer to produce sealants, adhesives, fibers, paper sizing, molded parts, water coagulants, and textiles. [ACGIH]

Comments

Can cause sensorimotor neuropathy after occupational exposure; [ACGIH] Allergic contact dermatitis reported in laboratory workers using polyacrylamide gels for electrophoresis; [Kanerva, p. 1738] In high-dose reproductive studies of animals, acrylamide can cause testicular damage and increased fetal losses; exposed fetuses may suffer neurotoxic effects. [Frazier, p. 333-4] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK]

Reference Link

OSHA: Acrylamide Exposure During Chemical Grouting Operations

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.03 mg/m3, inhalable fraction and vapor

PEL (OSHA)

0.3 mg/m3

IDLH (NIOSH)

60 mg/m3

Excerpts from Documentation for IDLHs

Calculations based on an oral LD50 of 150 to 180 mg/kg for guinea pigs, rabbits, and rats [McCollister et al. 1964] indicate that a worker should be able to escape within 30 minutes without injury or irreversible health effects from 600 mg/m3. . . . the revised IDLH for acrylamide is 60 mg/m3 based on being 2,000 times the OSHA PEL of 0.03 mg/m3 that was promulgated in 1989 (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the OSHA PEL). [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for acrylamide at concentrations above 0.03 mg/m3.]

Vapor Pressure

0.007 mm Hg

Half Life

Plasma (animal studies): 2 days; whole body (animal studies): 6-18 days; [TDR, p. 40]

Reference Link

HSDB: Acrylamide

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Sensorimotor Neuropathy

Reproductive Toxin

Yes

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: