Agent Name

N-Isopropyl-N'-phenyl-p-phenylenediamine

Alternative Name

4-(Isopropylamino)diphenylamine

CAS Number

101-72-4

Formula

C15-H18-N2

Major Category

Nitrogen Compounds

Synonyms

4-(Isopropylamino)diphenylamine; 1,4-Benzenediamine, N-(1-methylethyl)-N'-phenyl-; 4-Anilino-N-isopropylaniline; 4-Isopropylaminodiphenylamine; 4010 NA; 4010NA; ASM 4010MA; Antigen 3c; Antigene 3C; Antioxidant 4010 NA; Antioxidant 4010NA; Antioxidant 40NA; Antioxidant IP; Cyzone; Cyzone IP; Diafen FP; Diaphen FP; Elastozone 34; Flexzone 3C; IPPD; Ipognox 44; N-2-Propyl-N'-phenyl-p-phenylenediamine; N-Fenyl-N'-isopropyl-p-fenylendiamin [Czech]; N-Isopropyl-N'-fenyl-p-fenylendiamin [Czech]; N-Isopropyl-N'-phenyl-4-phenylenediamine; N-Isopropyl-N'-phenyl-para-phenylenediamine; N-Phenyl-N'-isopropyl-1,4-phenylenediamine; N-Phenyl-N'-isopropyl-p-phenylenediamine; NA 4010; Nocrac 810NA; Nocrack 810NA; Nonox ZA; Orflex PP; Ozonon 3C; Permanax 115; S-IP; Santoflex 36; Santoflex IP; p-Phenylenediamine, N-isopropyl-N'-phenyl-; para-Isopropylaminodiphenylamine; Benzenediamine, N-(1-methylethyl)-N'-phenyl-, 1,4-; [ChemIDplus] IPPD; [HSDB]

Category

Amines, Polyaromatic

Description

Dark grey to black solid; [Hawley] Brown, grey, or dark purple to black solid; [CHEMINFO]

Sources/Uses

Used to protect rubber against oxidation, ozone, and contamination by copper and manganese; [Hawley] Occupational exposures are mainly to rubber tires; [Kanerva, p. 1805]

Comments

A skin and eye irritant; May cause skin sensitization; [ICSC] Emergency treatment: "Paraphenylenediamine"; Paraphenylenediamine can cause angioneurotic edema, the most common cause of death after an overdose; Other effects after ingestion are vomiting, acute tubular necrosis, liver injury, methemoglobinemia, and seizures; p-Phenylenediamine is a skin and respiratory tract sensitizer; [HSDB] A skin, eye, and respiratory tract irritant; May cause contact dermatitis; [CAMEO] Does not readily penetrate intact skin; Not an eye or skin irritant based on animal studies; May cause skin sensitization; No data available on inhalation toxicity, respiratory sensitization, or carcinogenicity; [Reference #1] See "p-Phenylenediamine."

Reference Link

OECD SIDS: N-Isopropyl-N'-phenyl-p-phenylenediamine (IPPD) - 2000

Exposure Assessment
MAK

2 mg/m3, inhalable fraction

Vapor Pressure

7.11E-5 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: