Agent Name

Angelicin

CAS Number

523-50-2

Formula

C11-H6-O3

Major Category

Biological Agents

Synonyms

2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone; 2H-Furo(2,3-H)-1-benzopyran-2-one; 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; Angecin; Angelicin (coumarin derivative); Furo(2,3-h)coumarin; Furo(5',4':7,8)coumarin; Isopsoralen; Angelicin plus ultraviolet A radiation [Angelicins]; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [MSDSonline]

Sources/Uses

Found in many plants traditionally used as herbal remedies; Highly fluorescent; [HSDB] Present in plants of the Umbelliferae family; Clinically tested in combination with ultraviolet A radiation for the treatment of psoriasis; [IARC]

Comments

May cause photosensitization; Emergency treatment: "Psoralens"; Therapeutic doses (with UV light) are 0.6 mg/kg; Hepatitis has been reported after ingestion of herbal remedies and use of psoralen-UV therapy; [HSDB] Causes changes in liver weight and liver enzymes in feeding studies of mice; Causes altered sleep and ataxia in lethal dose feeding studies of rats; [RTECS] An irritant; Can cause photosensitization; [Aldrich MSDS]

Exposure Assessment
Vapor Pressure

2.24E-5 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Contact Dermatitis, Photoirritant

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: