Agent Name

Isosafrole

CAS Number

120-58-1

Formula

C10-H10-O2

Major Category

Other Classes

Synonyms

1,2-Methylenedioxy-4-propenylbenzene; 1,3-Benzodioxole, 5-(1-propenyl)-; 3,4-(Methylenedioxy)-1-propenylbenzene; 3,4-Methylenedioxy-1-propenyl benzene; 4-Propenyl-1,2-methylenedioxybenzene; 4-Propenylcatechol methylene ether; 5-(1-Propenyl)-1,3-benzodioxole; 6-(1-Propenyl)-1,3-benzodioxole; Izosafrol; [ChemIDplus]

Category

Other Aromatic Compounds

Description

Colorless liquid with an anise odor; [Hawley] Slightly yellow clear liquid; [MSDSonline]

Sources/Uses

Used to manufacture heliotropin, perfumes, pesticide synergists, root beer flavors, and soaps; [HSDB]

Comments

Emergency treatment: "Sassafras oil"; Safrole is the toxic agent in sassafras oil; Safrole is classified as 2B (possible human carcinogen) by IARC; Safrole is metabolized in the body to 1'-hydroxysafrole; Ingestion of 5 ml of sassafras oil can cause severe symptoms (tachycardia, hypotension, and respiratory paralysis) or death; Large doses may damage the liver; Drinking 10 cups of sassafras tea caused sweating in one adult subject; [HSDB] A skin irritant; Effects in high-dose animal studies include convulsions; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.02 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.