Agent Name

Isovaleric acid

CAS Number

503-74-2

Formula

C5-H10-O2

Major Category

Other Classes

Synonyms

3-Methylbutanoic acid; 3-Methylbutyrate; 3-Methylbutyric acid; Acetic acid, isopropyl-; Butanoic acid, 3-methyl-; Butyric acid, 3-methyl-; Delphinic acid; Isobutyl formic acid; Isobutylformic acid; Isopentanoic acid; Isopropylacetic acid; Isovalerianic acid; Isovaleric acid (natural); Kyselina isovalerova [Czech]; beta-Methylbutyric acid; [ChemIDplus]

Category

Organic Acids

Description

Liquid with a disagreeable odor like rancid cheese; [Merck Index] Clear colorless liquid with a disagreeable odor; [CHEMINFO]

Sources/Uses

Found in hop oil, tobacco, and other plants; [Merck Index] Used as a fragrance and flavor and to make fungicides, rodenticides, sedatives, narcotics, and other drugs; [HSDB] Used to make esters for solvents, softeners, and perfumes; [CHEMINFO]

Comments

Safe when used as a flavoring agent in food; [JECFA] Mild irritant when administered to eye of rabbit; Corrosive to skin of mice; Caused somnolence and ataxia in lethal-dose feeding studies of rats; [RTECS] Corrosive to tissue; [CAMEO] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; [CHEMINFO] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.44 mm Hg

Odor Threshold Low

0.0015 ppm

Odor Threshold High

0.72 ppm

Explanatory Notes

Odor threshold from CHEMINFO;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.