Agent Name

1-Nitropropane

CAS Number

108-03-2

Formula

C3-H7-N-O2

Major Category

Nitrogen Compounds

Synonyms

1-NP; 1-Nitropropane; [ChemIDplus] UN2608

Category

Nitros, Aliphatic

Description

Colorless liquid with a somewhat disagreeable odor; [NIOSH]

Sources/Uses

Used in organic chemical synthesis and as a rocket propellant, gasoline additive, and solvent; [ACGIH] Used as a solvent for waxes, resins, lacquers, synthetic rubber, fats, oils, dyes, inks, and other organic materials; [HSDB]

Comments

A hepatotoxin in animals after oral administration or inhalation; [ACGIH] An eye and respiratory tract irritant; [ICSC] Volunteers tolerated 100 ppm for 8 hours; 150 ppm caused irritation of the nose and throat; A weak inducer of methemoglobinemia; [CHEMINFO] Causes CNS depression and anesthesia in lethal concentration animal studies; [ChemIDplus] See "2-Nitropropane."

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

25 ppm

PEL (OSHA)

25 ppm

MAK

2 ppm

IDLH (NIOSH)

1000 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rabbits survived a 1hour exposure to 10,000 ppm [Machle et al. 1940]. Human data: Volunteers found brief exposures to concentrations exceeding 100 ppm to cause eye irritation [Silverman et al. 1946].

Vapor Pressure

10.1 mm Hg

Odor Threshold Low

7.7 ppm

Odor Threshold High

140 ppm

Lethal Concentration

LC50 (rat) = 3,100 ppm/8H

Explanatory Notes

Detection odor threshold from AIHA (mean = 140 ppm); Flash point = 36 deg C;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent:

Processes

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