Agent Name

Isoxathion

CAS Number

18854-01-8

Formula

C13-H16-N-O4-P-S

Major Category

Pesticides

Synonyms

E-48; Isoxathion [BSI:JMAF:ISO]; Karphos; O,O-Diethyl O-(3-(5-phenyl)-1,2-isoxazolyl)phosphorothionate; O,O-Diethyl O-(5-phenyl-3-isoxazolyl) phosphorothioate; SI-6711; Phosphorothioic acid, O,O-diethyl O-(5-phenyl-3-isoxazolyl) ester; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellowish liquid; [HSDB]

Sources/Uses

Used as contact and stomach insecticide for fruits, tea, tobacco, ornamentals, rice, sugarcane, vegetables, turf, and trees; [HSDB]

Comments

The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

No longer registered as a pesticide for use in the US; [HSDB] Banned in the EU for use as pesticide for plant protection; [eChemPortal: ESIS]

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

2.22E-6 mm Hg

Lethal Concentration

LC50 (rat) = 4,200 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: