Agent Name

Jervine

CAS Number

469-59-0

Formula

C27-H39-N-O3

Major Category

Biological Agents

Synonyms

Jervin; Jerwiny [Polish]; Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-; 17,23beta-Epoxy-3beta-hydroxyveratraman-11-one; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index]

Sources/Uses

A steroidal alkaloid present in the genus Veratrum; [Merck Index]

Comments

Emergency treatment: "Plants- veratrum alkaloids"; Excessive amounts can cause death by central respiratory depression; Symptoms begin 1/2 to 4 hours after ingestion and usually last 24 to 48 hours. Ingestion of 4-5 bulbs for a child and 40-50 bulbs for an adult may be fatal. [HSDB] Veratrum alkaloids (e.g., black snakeroot, false hellebore, and skunk cabbage) cause gastroenteritis, bradycardia, paresthesias, AV block, and syncope;; [Olson, p. 376-92] May cause irritation; Effects in high-dose animal studies include convulsions; [MSDSonline]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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