Agent Name

o-Nitrotoluene

Alternative Name

2-Nitrotoluene

CAS Number

88-72-2

Formula

C7-H7-N-O2

Major Category

Nitrogen Compounds

Synonyms

1-Methyl-2-nitrobenzene; 2-Methyl-1-nitrobenzene; 2-Methylnitrobenzene; 2-Nitrotoluene; 2-Nitrotoluol; Nitrotoluene, all isomers; ONT; Toluene, o-nitro-; o-Methylnitrobenzene; o-Nitrotoluene; o-Nitrotoluol; ortho-Nitrotoluol; [ChemIDplus] UN1664

Category

Nitros, Aromatic

Description

Yellow liquid with a weak, aromatic odor. [Note: A solid below 25 degrees F.]; [NIOSH]

Sources/Uses

Used in the production of dyes, pesticides, and rubber chemicals; [ACGIH]

Comments

Nitrotoluenes (all isomers) have the potential to induce methemoglobinemia in the same manner as aniline and nitrobenzene. [ACGIH] Irritating to the eyes; Can induce methemoglobinemia; [ICSC] Suspected germ cell mutagen (3B); [MAK]

Reference Link

IARC 2012: 2-Nitrotoluene

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

PEL (OSHA)

5 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Basis for revised IDLH: Based on acute oral toxicity data in animals [Back et al. 1972; Vasilerko et al. 1978] and an analogy to nitrobenzene [Linch 1974] which has an IDLH of 200 ppm, the original IDLH for nitrotoluene (200 ppm) is not being revised at this time.

Vapor Pressure

0.1 mm Hg

Odor Threshold Low

0.05 ppm

Lethal Concentration

LC50 (rat) = 790 mg/m3

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 95 deg C;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Primary

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: