Agent Name

Linalyl acetate

CAS Number

115-95-7

Formula

C12-H20-O2

Major Category

Biological Agents

Synonyms

1,6-Octadien-3-ol, 3,7-dimethyl-, acetate; 3,7-Dimethyl-1,6-octadien-3-ol acetate; 3,7-Dimethyl-1,6-octadien-3-yl acetate; Acetic acid linalool ester; Bergamiol; Bergamol; Bergamot mint oil; Ex bois de rose (synthetic); Licareol acetate; Linalol acetate; Linalool acetate; Linalyl acetate (natural); Lynalyl acetate; [ChemIDplus]

Category

Plant Oils and Extracts

Description

Clear colorless liquid with an odor of bergamot; [Hawley]

Sources/Uses

Present in bergamot, lavender, and other volatile oils; [Merck Index] Used in perfumes, soaps, cleaning products, cosmetics, oil paints, and flavoring extracts; [HSDB]

Comments

Emergency treatment: "Linalool"; [HSDB] Included in list of "established contact allergens in humans"; [ToxPlanet: EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] Causes somnolence and ataxia and acts as a general anesthetic in lethal dose studies of rats; [RTECS] Safe when used as a flavoring agent in food; [JECFA] Hydrolyzed in the GI tract into linalool and acetic acid; Not a mutagen; Not likely to be a sensitizer; Linalool, a hydrolysis product, caused "hepatocellular cytoplasmic vacuolisation" in 28-day feeding studies of rats; [Reference #1] See "Linalool."

Reference Link

OECD SIDS: Linalyl acetate - 2002

Exposure Assessment
Vapor Pressure

0.11 mm Hg

Odor Threshold Low

6.06 ppm

Lethal Concentration

LC50 (mice) > 1,028 mg/m3/4h

Explanatory Notes

Odor threshold from CHEMINFO;

Reference Link

Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens.

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: